Thereby causing the blue people begin to disappearing. For almost two centuries, the “blue skinned people of the Fugate family” lived in the areas of Troublesome Creek and Ball Creek in the hills of eastern Kentucky. Stemming from French immigrant Martin Fugate, who moved to Kentucky in 1820, the blue people were to become legends in their own right. In 1820, French orphan Martin Fugate and his wife Elizabeth Smith moved onto the banks of Troublesome Creek, a beautiful area in Appalachian Kentucky. Cawein had just started work at the University of Kentucky’s Lexington medical clinic. The most detailed account, "Blue People of Troublesome Creek," was published in 1982 by the University of Indiana's Cathy Trost. If a good friend of usually normal… Some reports say Martin was not blue but was a carrier of the methemoglobinemia gene. The ancestral line began with a French orphan, Martin Fugate… The progenitor of the Fugates family was a Frenchman by the name, Martin Fugate, who had traveled to America in 1820 in search of a better life. They eventually passed their unique characteristic from generation to generation, remaining largely isolated from the outside world. Apparently the arrival of coal mining in Kentucky in 1912 led to the Fugates moving away from Troublesome Creek. Origin of the Blue Fugates Family of Kentucky. The Fugates, a family that lived in the hills of Kentucky, commonly known as the "Blue Fugates" or the "Blue People of Kentucky", are notable for having been carriers of a genetic trait that led to the blood disorder methemoglobinemia, which causes the appearance of blue-tinged skin. Fugate, an orphan, settled down on a piece of land that had been left for him near Troublesome Creek … The Blue People of Kentucky Meanwhile, much earlier in 1960, the stories of the blue people of Troublesome Creek caught the attention of a young haematologist Dr. Madison Cawein. Due to a recessive gene, some members of the Fugate family have a bluish tint to their skin. There is no official record documenting that Martin was actually blue, but he and his wife both carried a recessive gene that gave their son Zachariah Fugate a startling blue color. Image: via NClark Illustration of Martin Fugate and his family. He published his research on the family in 1964 in the Archives of Internal Medicine and talked about how he tried to treat the family’s condition using methylene blue. The Fugate family of the Troublesome Creek region of Kentucky is but one example of a genetic disorder, scientifically known as Methemoglobinemia. 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